The study of intestinal regeneration is very significant to human health. Our work helps understand what happens in patients which have inflammatory diseases such as Crohn’s Disease or Ulcerative Colitis. As well, the treatment of cancer often results in gastrointestinal mucositis, a damaging of the intestinal epithelium by chemical agents. Understanding intestinal regeneration will help treat or avoid these side effects. Finally, regeneration can lead to cancer because the activation of stem cells turns on genes involved in growth and proliferation. Thus we are interested in exploring the relationships between healing and tumorigenesis.
The Circadian Clock is an ancient and evolutionarily conserved pathway. We are interested in studying how time of day regulates regeneration in mammals, such as mice, and how this is connected to inflammation, growth and cancer.