The emergence of circadian timekeeping in the intestine. K. Parasram, A. Zuccato, M. Shin, R. Willms, B. Deveale, E. Foley, P. Karpowicz. (under review, 2023, bioRxiv doi: https://doi.org/10.1101/2023.06.06.543952,).
Fluorescent reporters for studying circadian rhythms in Drosophila melanogaster. K. Parasram, D. Bachetti, V. Carmona-Alcocer, P. Karpowicz. Methods in Molecular Biology 2482: 353 – 371 (2022).
Bmal1 regulates the daily timing of colitis. Z. Taleb, V. Carmona-Alcocer, K. Stokes, M. Haireek, H. Wang, S. Collins, W.I. Khan, P. Karpowicz. Frontiers in Cellular and Infection Microbiology 12: 773413 (2022).
The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation. K. Stokes, M. Nunes, Trombley, D. E. F. L. Flores, G. Wu, Z. Taleb, A. Alkhateeb, S. Banskota, C. Harris, O. Love, W.I. Khan, L. Rueda, J.B. Hogenesch, P. Karpowicz. Cellular & Molecular Gastroenterology and Hepatology 12(5): 1847 – 1872 (2021).
Time after time: Circadian clock regulation of intestinal stem cells. K. Parasram, P. Karpowicz. Cellular and Molecular Life Sciences 77(7): 1267 – 1288 (2020).
Impaired ECM Remodeling and Macrophage Activity Define Necrosis and Regeneration Following Damage in Aged Skeletal Muscle. F. Rahman, S. Angus, K. Stokes, P. Karpowicz. Krause M. International Journal of Molecular Sciences 21(13): 4575 (2020).
Intestinal stem cells exhibit conditional circadian clock function. K. Parasram, N. Bernardon, M. Hammoud, H. Chang, L. He, N. Perrimon, P. Karpowicz. Stem Cell Reports 11(5): 1287 – 1301 (2018).
Testing the expression of circadian clock genes in the tissues of Chinook salmon, Oncorhynchus tshawytscha, Chronobiology International, 36:8, 1088 – 1102 (2019)
Stokes, K., Cooke, A., Chang, H., Weaver, D.R., Breault, D.T., Karpowicz, P. The circadian clock gene BMAL1 coordinates intestinal regeneration. Cellular & Molecular Gastroenterology and Hepatology 4(1): 95 – 114 (2017).
Amin, R., Karpowicz, P., Carey, T.E., Arbiser, J., Nahta, R., Chen, Z.G., Dong, J‑T., Kucuk, O., Khan, G.N., Huang, G.S., Lee, H‑Y., Reichrath, J., Honoki, K., Georgakilas, A.G., Amedei, A., Amin, A., Helferich, B., Boosani, C.S., Ciriolo, M.R., Chen, S., Mohammed, S.I., Azmi, A.S., Keith, W.N., Bhakta, D., Halicka, D., Niccolai, E., Fujii, H., Aquilano, K., Ashraf, S.S., Nowsheen, S., Yang, X., Bilsland, A, Shin, D.M. Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Seminars in Cancer Biology 35: S55-77 (2015).
Block, K.I., et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology 35: S276-304 (2015).
Karpowicz, P., Zhang, Y., Hogenesch, J.B., Emery, P., Perrimon, N. The circadian clock gates the intestinal stem cell regenerative state. Cell Reports 3(4): 996‑1004 (2013).
DeVeale, B., Bausch-Fluck, D., Seaberg, R., Runciman, S., Akbarian, V., Karpowicz, P., Yoon, C., Song, H., Zandstra, P., Wollscheid, B., van der Kooy, D. Surfaceome profiling reveals regulators of neural stem cell function. Stem Cells 32(1): 258 – 68 (2013).
Smukler, S.R., Arntfield, M.E., Razavi, R., Bikopoulos, G., Karpowicz, P., Seaberg, R., Dai, F., Lee, S., Ahrens, R., Fraser, P., Wheeler, M., van der Kooy, D. The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin. Cell Stem Cell. 8(3): 281 – 93. (2011).
Ni, J.Q., Zhou, R., Czech, B., Liu, L., Holderbaum, L., Yang-Zhou, D., Shim, H.S., Tao, R., Handler, D., Karpowicz, P., Binari, R., Booker, M., Brennecke, J., Perkins, L.A., Hannon, G.J., Perrimon, N. A Genome-Scale shRNA Resource for Transgenic RNAi in Drosophila. Nature Methods. 8(5): 405 – 7. (2011).
Karpowicz, P., Perez, J., Perrimon, N. The Hippo Tumor Suppressor Pathway Regulates Intestinal Stem Cell Regeneration. Development 137(24): 4135 – 45 (2010).
Karpowicz, P., Perrimon, N. All for One and One for All: The Clonality of the Intestinal Stem Cell Niche. F1000 Biology Reports 2:73 (2010).
Karpowicz, P., Biased DNA Segregation. Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: [DOI: 10.1002/9780470015902.a0022543] (2010).
Karpowicz, P., Response to Letter from Renata Maas. DNA Repair. 9: 1024 – 25 (2010).
Karpowicz, P., Willaime-Morawek, S., Inoue, T., Deveale, B., Hitoshi, van der Kooy, D. E‑Cadherin Regulates Neural Stem Cell Self-Renewal. Journal of Neuroscience. 29(12): 3885 – 96. (2009).
Karpowicz, P., Pellikka, M., Godt, D., Tepass, U. The germline stem cells of Drosophila melanogaster partition DNA non-randomly. European Journal of Cell Biology. 88(7): 397 – 408. (2009).
Coles-Takabe, B.L., Brain, I., Purpura, K.A., Karpowicz, P., Zandstra, P.W., Morshead, C.M., van der Kooy, D. Don’t Look: Growing clonal versus non-clonal neural stem cell colonies. Stem Cells. 26(11): 2938 – 44. (2008).
Karpowicz, P., Inoue, T., Runciman, S., Chaddah, R., Seaberg, R., Gertsenstein, M., Byers, L., Yamanaka, Y., Tondat, S., Slevin, J., Hitoshi, S., Rossant, J., van der Kooy, D. Adhesion Is Prerequisite But, Alone, Is Insufficient for Neural Stem Cell Pluripotency. Journal of Neuroscience. 27(20): 5437 – 47. (2007).
Karpowicz, P., Morshead, C., Kam, A., Jervis, E., Cheng, V., van der Kooy, D. Support for the Immortal Strand Hypothesis: Neural Stem Cells Partition DNA Asymmetrically in vitro. Journal of Cell Biology. 170(5): 721 – 32. (2005).
Karpowicz, P., Cohen, C., van der Kooy, D. Developing Human/Nonhuman Chimeras in Human Stem Cell Research: Ethical Issues and Boundaries. Kennedy Institute of Ethics Journal. 15(2): 107 – 34. (2005).
Karpowicz, P., Cohen, C., van der Kooy, D. It is Ethical To Transplant Human Stem Cells into Nonhuman Embryos. Nature Medicine. 10(3): 331 – 5. (2004).
Stewart, J.M., Blakely, J.A., Karpowicz, P., Martin, B.M., Thatcher, B. Unusually weak oxygen binding, physical properties, partial sequence, autoxidation rate and a potential phosphorylation site of beluga whale (Delphinapterus leucas) myoglobin. Comp Biochem Physiol B Biochem Mol Biol. 137(3): 401 – 12. (2004).
Karpowicz, P. In Defense of Stem Cell Chimeras: A Response to ‘Crossing Species Boundaries’. American Journal of Bioethics. 3(3): w17-19. (2003).