karpowicz_lab_monogram_only_white@2

Publications

2018

Intesti­nal stem cells exhibit con­di­tional cir­ca­dian clock function. K. Parasram, N. Bernar­don, M. Hammoud, H. Chang, L. He, N. Perrimon, P. Kar­pow­icz. Stem Cell Reports (in press — 2018)

Cir­ca­dian clock function occurs in a tissue-specific manner in Oncorhynchus tshawytscha. M. Thraya, M. Hammoud, S. Rao, T. Pitcher, D. Heath, P. Kar­pow­icz. (in prepa­ra­tion)

2017

Stokes, K., Cooke, A., Chang, H., Weaver, D.R., Breault, D.T., Kar­pow­icz, P. The cir­ca­dian clock gene BMAL1 coor­di­nates intesti­nal regen­er­a­tion. Cellular & Mol­e­c­u­lar Gas­troen­terol­ogy and Hepa­tol­ogy 4(1): 95 – 114 (2017).

2015

Amin, R., Kar­pow­icz, P., Carey, T.E., Arbiser, J., Nahta, R., Chen, Z.G., Dong, J-T., Kucuk, O., Khan, G.N., Huang, G.S., Lee, H-Y., Reichrath, J., Honoki, K., Geor­gak­i­las, A.G., Amedei, A., Amin, A., Helferich, B., Boosani, C.S., Ciriolo, M.R., Chen, S., Mohammed, S.I., Azmi, A.S., Keith, W.N., Bhakta, D., Halicka, D., Niccolai, E., Fujii, H., Aquilano, K., Ashraf, S.S., Nowsheen, S., Yang, X., Bilsland, A, Shin, D.M. Evasion of anti-growth sig­nal­ing: a key step in tumori­ge­n­e­sis and poten­tial target for treat­ment and pro­phy­laxis by natural com­pounds. Seminars in Cancer Biology 35: S55-77 (2015).

Block, K.I., et al. Design­ing a broad-spectrum inte­gra­tive approach for cancer pre­ven­tion and treat­ment. Seminars in Cancer Biology 35: S276-304 (2015).

2013

Kar­pow­icz, P., Zhang, Y., Hogenesch, J.B., Emery, P., Perrimon, N. The cir­ca­dian clock gates the intesti­nal stem cell regen­er­a­tive state. Cell Reports 3(4): 996‑1004 (2013).

DeVeale, B., Bausch-Fluck, D., Seaberg, R., Runciman, S., Akbarian, V., Kar­pow­icz, P., Yoon, C., Song, H., Zandstra, P., Wollscheid, B., van der Kooy, D. Sur­faceome pro­fil­ing reveals reg­u­la­tors of neural stem cell function. Stem Cells 32(1): 258 – 68 (2013).

2011

Smukler, S.R., Arnt­field, M.E., Razavi, R., Bikopou­los, G., Kar­pow­icz, P., Seaberg, R., Dai, F., Lee, S., Ahrens, R., Fraser, P., Wheeler, M., van der Kooy, D. The Adult Mouse and Human Pancreas Contain Rare Mul­ti­po­tent Stem Cells that Express Insulin. Cell Stem Cell. 8(3): 281 – 93. (2011).

Ni, J.Q., Zhou, R., Czech, B., Liu, L., Holder­baum, L., Yang-Zhou, D., Shim, H.S., Tao, R., Handler, D., Kar­pow­icz, P., Binari, R., Booker, M., Bren­necke, J., Perkins, L.A., Hannon, G.J., Perrimon, N. A Genome-Scale shRNA Resource for Trans­genic RNAi in Drosophila. Nature Methods. 8(5): 405 – 7. (2011).

2010

Kar­pow­icz, P., Perez, J., Perrimon, N. The Hippo Tumor Sup­pres­sor Pathway Reg­u­lates Intesti­nal Stem Cell Regen­er­a­tion. Devel­op­ment 137(24): 4135 – 45 (2010).

Kar­pow­icz, P., Perrimon, N. All for One and One for All: The Clon­al­ity of the Intesti­nal Stem Cell Niche. F1000 Biology Reports 2:73 (2010).

Kar­pow­icz, P., Biased DNA Seg­re­ga­tion. Ency­clo­pe­dia of Life Sciences. John Wiley & Sons, Ltd: [DOI: 10.1002/9780470015902.a0022543] (2010).

Kar­pow­icz, P., Response to Letter from Renata Maas. DNA Repair. 9: 1024 – 25 (2010).

2009

Kar­pow­icz, P., Willaime-Morawek, S., Inoue, T., Deveale, B., Hitoshi, van der Kooy, D. E-Cadherin Reg­u­lates Neural Stem Cell Self-Renewal. Journal of Neu­ro­science. 29(12): 3885 – 96. (2009).

Kar­pow­icz, P., Pellikka, M., Godt, D., Tepass, U. The germline stem cells of Drosophila melanogaster par­ti­tion DNA non-randomly. European Journal of Cell Biology. 88(7): 397 – 408. (2009).

2008

Coles-Takabe, B.L., Brain, I., Purpura, K.A., Kar­pow­icz, P., Zandstra, P.W., Morshead, C.M., van der Kooy, D. Don’t Look: Growing clonal versus non-clonal neural stem cell colonies. Stem Cells. 26(11): 2938 – 44. (2008).

2007

Kar­pow­icz, P., Inoue, T., Runciman, S., Chaddah, R., Seaberg, R., Gert­sen­stein, M., Byers, L., Yamanaka, Y., Tondat, S., Slevin, J., Hitoshi, S., Rossant, J., van der Kooy, D. Adhesion Is Pre­req­ui­site But, Alone, Is Insuf­fi­cient for Neural Stem Cell Pluripo­tency. Journal of Neu­ro­science. 27(20): 5437 – 47. (2007).

2005

Kar­pow­icz, P., Morshead, C., Kam, A., Jervis, E., Cheng, V., van der Kooy, D. Support for the Immortal Strand Hypoth­e­sis: Neural Stem Cells Par­ti­tion DNA Asym­met­ri­cally in vitro. Journal of Cell Biology. 170(5): 721 – 32. (2005).

Kar­pow­icz, P., Cohen, C., van der Kooy, D. Devel­op­ing Human/Nonhuman Chimeras in Human Stem Cell Research: Ethical Issues and Bound­aries. Kennedy Insti­tute of Ethics Journal. 15(2): 107 – 34. (2005).

2004

Kar­pow­icz, P., Cohen, C., van der Kooy, D. It is Ethical To Trans­plant Human Stem Cells into Nonhuman Embryos. Nature Medicine. 10(3): 331 – 5. (2004).

Stewart, J.M., Blakely, J.A., Kar­pow­icz, P., Martin, B.M., Thatcher, B. Unusu­ally weak oxygen binding, physical prop­er­ties, partial sequence, autox­i­da­tion rate and a poten­tial phos­pho­ry­la­tion site of beluga whale (Del­phi­napterus leucas) myo­glo­bin. Comp Biochem Physiol B Biochem Mol Biol. 137(3): 401 – 12. (2004).

2003

Kar­pow­icz, P. In Defense of Stem Cell Chimeras: A Response to ‘Crossing Species Bound­aries’. American Journal of Bioethics. 3(3): w17-19. (2003).